2019 Chevy Volt Bolt EV Pass Automobile Mag noboringcars Test

Author Liberty Access TechnologiesPosted on October 1, 2018Categories Electric Vehicle News Source: Electric Vehicle News First, he took the reigns of a Chevy Bolt sporting the new Slate Gray Metallic paint. He took the cars on a mixture of curved highways and country roads in the area around Burlington, Vermont.My tester handled the route with hot hatch-baiting poise.The Bolt EV leaps off the line and torches its front tires if the operator isn’t wary of the substantial 266 lb-ft of torque available from a standstill.The 200-hp performed well when passing on the two-lane roads. The high regenerative braking and regen paddle and 238 miles of range made for a low-stress driving experience. In a differing opinion from many recent reviewers, Rehbock had no issue with the front or back seats.The Bolt, with its slim yet supportive seats, even impressed me as a back-seat passenger with its generous leg room. Automobile Magazine Thunderdome: Two Chevy’s enter; both Chevy’s leave with high marks. But one gets the bigger nod.Automobile Magazine reviewer and social media editor Billy Rehbock recently took some time to check out the newly updated 2019 Chevy Volt and Chevy Bolt EVs. Rehbock wanted to see if the Chevrolet electrics fit the bill for the magazine’s #noboringcars mantra.More About Chevy Electrics Chevy Sales Estimates: Volt Hits Yearly High, Bolt Begins To Climb 2.5 Years, 25k Miles On A Chevy Volt: Should It Stay Or Should It Go? 29 photos Save On Chevy Bolt, Volt: GM Launches Assistance For Storm Victims On the refreshed Chevy Volt, the reviewer felt that the plug-in hybrid had a lot of good qualities as well. Acceleration isn’t as sporty as the Bolt, but there is enough power to offer the occasionally exciting driving experience. Steering and handling have also improved since the last time he took a Volt for a spin.The Volt interior was sculpted well and the material quality was high, but did not like the mismatch between materials used on the door sills and the dash. Like a lot of reviewers, Automotive Magazine finds the low-rolling resistance tires on these cars aren’t ideal. Both cars offered a nice, quiet ride on electric power. Rehbock blew through the 53 miles of electric range quite quickly with his somewhat aggressive driving, however.So both cars impressed overall. For those that look down upon electric vehicles, Rehbock wants to set the record straight:Sometimes, folks seem to knock some of the more mundane electric cars for not being the best fit for our #noboringcars mantra.…As far as my #noboringcars assessment went, this dynamic duo had enough driving chops and techie gadgets to pass the test.But which one came away as the reviewers favorite? Check out the full article below.Source: Automobile MagazineCHEVY BOLT read more

Byton MByte Electric SUV The EV Dark Horse Video

first_imgSean saw the M-Byte and the K-Byte for the first time at the recent LA Auto Show. In this video, he focuses on Byton’s tech, the M-Byte’s performance, and the financial and leadership aspects of the company as a whole. As we’ve stated on numerous occasions, our own Tom Moloughney has been working closely with Byton and has spent a great deal of time with its prototypes. As far as Tom is concerned, Byton seems to have what it takes to become a viable force in the EV segment.Why does Sean call the M-Byte the EV dark horse?Sean seems to agree with Tom. Not much is known about Byton, but its vehicles appear to have the potential to become solid competitors in the EV space in the not-so-far future. First of all, its massive infotainment display is incredibly impressive. The company says its vehicles will be the world’s first “smart” and “intuitive” vehicles. The automaker also has plans to partner with Amazon Alexa, but even without Alexa, its prototypes feature innovative technologies that have never been seen before in a production vehicle.Byton is actively raising money through multiple funding rounds. Thus far, the company has raised about $700 million. While that’s a lot of money, much more will be needed to get production off the ground. In addition to its work on financing, Byton has a compelling list of executives at the helm.As with any automotive startup, the road will be long and it’s not going to be easy. Rivian is in a similar situation in terms of having great products, money coming in, and top-level leaders. However, consider the fact that Tesla has been at this for many years and is just beginning to make notable progress.What do you think of Byton? Moreover, do you believe the M-Byte will make it to production? Let us know in the comment section below.Video Description via Sean Mitchell on YouTube:Byton M-Byte: The EV dark horse BYTON Electric SUV Enters Testing Phase Author Liberty Access TechnologiesPosted on December 11, 2018Categories Electric Vehicle News Source: Electric Vehicle News Let’s take a deep dive into the upcoming Byton M-Byte electric SUV.Sean Mitchell from AllThingsEV.info calls the M-Byte the EV dark horse, so we’re going to take a look at his reasoning. Just the other day, we shared Sean’s video comparing the Byton SUV to the Tesla Model S and Model X. Now, he provides us with a more in-depth look into the M-Byte.Additional Byton Content: Byton M-Byte Crossover Specs Versus Tesla Model S And Model X See The Byton M-Byte Electric SUV Up Closelast_img read more

Check Out This Custom Electric BMW Motorcycle

first_img Vigo Electric Motorcycle Promises 400 Miles Of Range Source: Electric Vehicle News Most recently, LUUC.MUIS.CREATIONS was inspired by Barbara Custom Motorcycles to design an e-bike prototype that merges a stripped-down 1970’s BMW R80 with its own version of an electric motor called the E-drive.  Specifically tailored for this project concept, Muis reuses the engine crankcase of the R combustion engine exchanging, as he explains, “the entire engine with an Electric drive-train while keeping the BMW aesthetics of the R engine.”However, the bike is not just beautiful to behold, it would also deliver a holistic riding experience, which Muis believes is not just part of the pleasure but also a factor directly linked to safety.  After all, much of the understanding we have of our bikes while we ride is communicated through sounds, smells, and sensations.For Muis it’s simple: “Give E-drive the sense of functional sound, the sound to indicate: the engine is on, someone is approaching, acceleration, speed, malfunction (we have all heard the weird ticking noises in our cars at some point). This sound could easily be generated through mechanical principles since it’s nothing else than frequency air displacement.”Additionally, Muis insists that we relate strongly through the movement and handling of a regular bike, characteristics that don’t need to be lost to the typical one-gear e-bike motor.  Instead, he suggests adding a gearbox, which “keeps the experience of doing something with your machine,” an interaction that can help keep riders safe.All this comes in a gorgeous package, one that references the popular vintage roots of the R80 with more modern, seemingly weightless touches like the floating saddle, silvery spokes, dropped bars and original tank repurposed as a central hub.Yes, please.SOURCES: Luuc Muis Creations, Barbara Custom Motorcycles Lightning Motorcycles Is Moving To A New Facility Watch Tesla Model 3 Autopilot Detect Lane-Splitting Motorcycles An electrifying classic BMW.Dutch product designer Luuc Muis takes pleasure in the finer things in life—incredible craftsmanship, technology, a good steak and everything about riding a motorcycle.  That’s why his innovations are not only sleek but also include attention to every sensory detail.More E-Bikes Author Liberty Access TechnologiesPosted on December 27, 2018Categories Electric Vehicle Newslast_img read more

Sepion receives CEC grant for composite battery membranes

first_imgSource: California Energy Commission Source: Electric Vehicles Magazine The California Energy Commission (CEC) has awarded $450,000 in grant funding to Sepion Technologies, an Emeryville, California company that’s developing a composite battery membrane designed to replace ceramic components.Sepion’s composite membranes  provide high-flux and ion-selective transport, and the company says they can be processed in large-area formats at a fraction of the cost of ceramics.The project’s goal is to scale a prototype battery membrane that enables drop-in, roll-to-roll manufacturing of lithium-metal anode batteries with significantly greater energy density compared to traditional graphite anode batteries.Sepion hopes the composite membrane will maintain all the safety characteristics and competitive costs of traditional lithium-ion batteries by avoiding the need for large-scale reconfiguration of existing manufacturing lines.With previous funding from the CEC, Sepion demonstrated its membrane’s ability to support stable cycling with lithium-metal anode batteries. Sepion plans to use the additional funding to scale up production to 100 kg batches with roll-to-roll manufacturing.last_img read more

Teslas Lathrop Site Appears To Be A Parts Distribution Center Video

first_imgWill Tesla’s mammoth site in Northern California be operational soon?Recent drone footage from YouTuber Troopr1023 shows more progress on the 870,000 square-foot  Tesla Lathrop facility, which is about 70 miles east of the Fremont factory. It appears that construction is progressing well, at least in terms of the building’s exterior and grounds. As you can see, the area around the building is coming together nicely, with the recent addition of asphalt, loading bays, and a large white tent similar to the one in Fremont.More On Tesla’s Lathrop Facility: Teslarati explains that the “numerous truck-sized loading bays denote shipping activity.” In addition, there are few parking spaces for employees. The publication also points out that job postings refer to the Lathrop site as a Parts Distribution Center.Tesla is looking for a motivated and experienced Supervisor for our highly dynamic parts distribution center in Lathrop, CA. This position will provide supervision of day-to-day operations including receiving, stocking, shipping and all transactions related to said activities. The Supervisor, Parts & Service Warehouse, will also ensure efficiency and accuracy of stocking and organizing parts inventory.The Lathrop facility is in addition to another 500,000 square-foot building that Tesla purchased from Chrysler. Interesting, Chrysler used that structure as a parts distribution center in the past.We have no indication when the building will be operational, however, continuous progress is clear.Video Description via Troopr1023 on YouTube:Tesla Lathrop Distribution Center Update (Jan. 27, 2019): Asphalt for Parking Lots & Loading BaysThe outer shell of Tesla’s distribution center in Lathrop is complete. Some raw materials and tools can still be seen on the roof, but the roof appears more or less complete at this point. Asphalt is being laid down for the parking lots and by the loading bays. It appears as if work is being done inside the building as well, but it was hard to see from the drone on the outside. Some of the glass has been installed by the office part of the building. There was no activity today (Sunday). There was no electromagnetic interference today as I experienced on another day. The video is shorter than normal because of a low controller battery. A white tent, similar to the tent in Fremont where the Model 3s are built, can be seen to the East of this location.Tesla’s old location at Louise remains empty. In the summer of 2018, thousands of Tesla vehicles were parked in the parking lot and dirt lot. Now, car carriers are still parked in the parking lot, and the dirt field looks like it is being leveled for construction. The smoke stack has been demolished.Tesla’s old location at Harlan looks to have new tenants. Many big rig trailers are now parked in the parking lot and on the back side of the building. I did not see any activity there today. General Public Can Now Order Own Tesla Model 3, S & X Parts Source: Electric Vehicle News Tesla Expanding In California With Massive New Building Author Liberty Access TechnologiesPosted on January 30, 2019Categories Electric Vehicle News Tesla’s Lathrop Facility Now Nearly Complete On Outside: Videolast_img read more

FCA invests in factories to enable plugin Jeep production possible allelectric vehicles

first_imgFiat Chrysler Automobiles (FCA) announced that it is investing $4.5 billion in five of its existing Michigan factories and part of that investment is going to enable plug-in electric Jeep production and possibly all-electric vehicle production in the future. more…The post FCA invests in factories to enable plug-in Jeep production, possible all-electric vehicles appeared first on Electrek. Source: Charge Forwardlast_img

In April 2019 PlugIn EV Car Sales In Germany Increased 34

first_imgTesla Model 3 this time was behind the Renault ZOE, BMW i3 and Mitsubishi Outlander PHEVSource: Electric Vehicle Newslast_img

Tritium Secures New Order From IONITY For Hundreds Of Chargers

first_imgWith the second order for ultra-fast chargers at 120 new sites, Tritium is now the largest supplier to the IONITY network.Source: Electric Vehicle Newslast_img

Tesla Model X gets turned into police patrol car of the future

first_imgThe Victoria police in Australia are deploying a new Tesla Model X as part of their fleet and they see the electric vehicle as “the future of road policing.”Tesla is reportedly working with the police department to integrate features into the main screen. more…Subscribe to Electrek on YouTube for exclusive videos and subscribe to the podcast.https://www.youtube.com/watch?v=V1zk7Eb8r-s&list=PL_Qf0A10763mA7Byw9ncZqxjke6Gjz0MtThe post Tesla Model X gets turned into ‘police patrol car of the future’, Tesla is working to integrate police features appeared first on Electrek. Source: Charge Forwardlast_img read more

Chicago Event Notice – Feb 22nd

first_imgOn February 22nd, Seyfarth Shaw LLP will be hosting me for a free FCPA workshop focused on FCPA fundamentals and issue-spotting. Andrew S. Boutros (Seyfarth Shaw National Co-Chair of White Collar, Internal Investigations, and False Claims Team) will join me in conducting the workshop.There is no cost to attend but registration is required and seating is limited. To learn more and to register click here.CLE credit is available.last_img

This Week On FCPA Professor

first_imgFCPA Professor has been described as “the Wall Street Journal concerning all things FCPA-related,” and “the most authoritative source for those seeking to understand and apply the FCPA.”Set forth below are the topics discussed this week on FCPA Professor.As highlighted in this post, recent survey results seriously call into question whether the FCPA has been successful in achieving its objectives.The question was recently posed: “why do ‘normal’ employees violate the FCPA?” As highlighted in this post, a partial answer is because FCPA enforcement actions often involve “normal” activity.This FCPA Flash podcast episode is a conversation with former DOJ FCPA prosecutor Bruce Searby regarding recent internship and hiring practices enforcement actions.Earlier this week professionals from all over the world and from leading firms and companies came to Seattle to elevate their Foreign Corrupt Practices Act knowledge and practical skills at the FCPA Institute. As highlighted here, the next stop for the FCPA Institute is Philadelphia on October 18-19, 2018.This post checks in on Wal-Mart’s pre-enforcement action professional fees and expenses.Summer. A time for reflection, a time to think, a time to read. If you have some downtime, put it to good use. This post provides an overview of FCPA writings that can help you elevate your Foreign Corrupt Practices Act knowledge, sophistication, and practical skills. How much do you know about the Foreign Corrupt Practices Act? Let’s find out in this week’s FCPA challenge.last_img read more

Does Elder Wisdom Exist

first_imgby, Jeanette Leardi, ChangingAging ContributorTweet55Share86Share18Email159 SharesIs there such a thing as “elder wisdom”? Do older adults inevitably acquire a special kind of inner knowledge unavailable in their middle-age years, or is this concept a mere stereotype and illusion?Culturally, we tend to romanticize the notion that everyone gets smarter with age and that for this reason, age alone demands our respect. But this assumption has its pitfalls.“I dislike the term ‘elder wisdom’ as it seems to have gone the way of cliché or token prize with a hefty dose of condescension,” says geriatrician and University of California San Francisco professor of medicine Dr. Louise Aronson, author of A History of the Present Illness. “Wisdom means using experience, knowledge and judgment well, so there is likely something real to older adults having wisdom since they have more experience, although more of something doesn’t guarantee quality, so this seems a generalization that will often fail, as most do, since one can have experience and learn little.”Tim Carpenter, CEO and founder of EngAGE, a nonprofit organization that “creates community and changes lives by transforming affordable senior and multigenerational housing projects into vibrant centers of learning, wellness, and creativity,” shares Aronson’s views. He believes that “people accumulate knowledge and experience throughout their lifespan and we all, as we age, better prioritize the things we need to know and know how to apply them in our daily lives. I think wisdom is something we all aspire to and there is a better chance of achieving it the longer we strive toward it. That said, simply becoming older doesn’t make us wise. Becoming older doesn’t make us anything –– kinder, more giving, better people. These are things we have to work for at any age, things we must earn.”The Traits of Elder Wisdom“Wisdom is not an inevitable product of aging,” says geriatric neuropsychiatrist and past president of the American Psychiatric Association Dilip Jeste. Furthermore, wisdom is more than mere knowledge passively derived from experience. It’s an ability that requires conscious and careful cultivation. “Wise people are intelligent,” he says, “but not all intelligent people are wise.”In an enlightening TEDMed talk, Jeste asserts that throughout history as well as cross-culturally, wisdom is defined by the following traits:Social decision making –– reasoning and acting in ways that consider the effects on other people;Emotional stability –– appropriately being able to control one’s own emotions;Pro-social behaviors (compassion, altruism, etc.) –– not being selfish but rather helping others;Insight –– knowing one’s own strengths and limitations; andDecisiveness amid uncertainty –– being open to other perspectives and suggestions and yet being able to act when necessary.Of course, these abilities can be found in any adult at any age, but Jeste says that older adults tend to exhibit more of these traits more often. Aronson agrees: “There is evidence for greater emotional intelligence with age, for many older adults being more sanguine about life, finding it easier to prioritize and take the wider view of things, putting them into perspective.”According to Jeste, human brains change throughout the lifespan, and elders engage more of their prefrontal cortex (the planning, organizing, and judging area of the brain), than do younger people. In addition, the two amygdalae of the brain, sub-organs that regulate a person’s emotions, are often calmer and less skewed toward negative feelings in older adults, which explains why people usually feel happier as they get older.The Purpose of Elder WisdomJeste believes there’s a special evolutionary purpose to elder wisdom, one that explains why people live decades past their ability to reproduce and past their maximum level of  physical strength. Citing what is known as the “grandmother hypothesis,” he explains that children who are reared with the help of infertile grandparents are more fertile when they become adults, and this helps to ensure a population’s survival.Exactly what kind of help do grandparents and other elders provide?  Whether or not they are involved in actual child-care duties, older adults contribute to the intellectual and moral growth of younger members of society.In his ground-breaking book From Age-ing to Sage-ing: A Revolutionary Approach to Growing Older, Zalman Schachter-Shalomi explains their significant contributions. “What do elders have to teach?” he asks. “Over and beyond an exchange of verbal information and technical skills, they transmit what can’t be acquired from books. When the transfer of sheer data just isn’t sufficient, they impart the wisdom of a lifetime (including the personal attitudes, moral and ethical judgments, and aesthetic appreciations that characterized them) through the fire of a unique relationship, the give-and-take of a living dialogue with a younger student or apprentice. When an elder fertilizes a young person’s aspiring mind with his knowledge and seasoned judgment, the student receives a living spark, a transmission, that may one day blossom into wisdom.”Inevitable vs. Potential WisdomWhen asking the question “Does ‘elder wisdom’ exist?”, it’s important to distinguish between what is (or isn’t) an inevitable fact and what is empirically a potential ability. The difference is a matter of the older adult actively committing to become wise. Says Carpenter: “I have worked with older people for decades, and I often tell them that they shouldn’t expect special treatment because they are older. We shouldn’t expect respect, we should live our lives in a way that earns the respect of others. If you’re looking for a handout because you’re older, you’ve already given away your power. The best examples of elder wisdom for me have always been in people who have tried hard to learn, to grow, to be open to ideas, to listen, to live life like it’s the only one they have.”“We’re not always elders; sometimes we’re aging, crotchety, somewhat elderly people,” writes Schachter-Shalomi. “But at any moment in the battle between the forces of aging and eldering, we can become conscious, snap out of the hypnotic trance induced by society and our own inertia, and do the inner work of eldering.”Perhaps the truest statement on elder wisdom is best expressed by Henry Wadsworth Longfellow in his poem “Morituri Salutamus”:“For age is opportunity no lessThan youth itself, though in another dress,And as the evening twilight fades awayThe sky is filled with stars, invisible by day.”The key word is “opportunity.” Older adults have the potential to acquire elder wisdom if and only if they take advantage of both the opportunity and the desire to reflect on their own life, make sense of it, and apply their insight toward positive engagement with the world.After all, those invisible stars will remain hidden unless and until elders choose to embrace the evening of their lives and let them shine.Related PostsThe Wisdom of Elderhood; Fact or Fiction?There is a common cultural ideal that the older one gets, the wiser one grows.  Perhaps that is why we say “there’s no fool like an old fool” — by the time you’ve reached a certain age, you’re supposed to know better. But is it true that with age comes…Elders Rock!Our world has been run by mere adults without Elder supervision for too long.Who is Dr. Bill Thomas?Tweet55Share86Share18Email159 SharesTags: EngageAge Tim Carpenter wisdomlast_img read more

UCLA researchers have blueprint of telomerase that plays major role in cancer

first_imgJun 7 2018Cancer, aging-related diseases and other illnesses are closely tied to an important enzyme called “telomerase.” UCLA researchers report in the journal Cell the deepest scientific understanding yet of this once-mysterious enzyme, whose catalytic core — where most of its activity occurs — can now be seen in near atomic resolution.”We’re now seeing not just the face of the clock, we’re seeing how the components inside interact to make it work,” said Juli Feigon, a professor of chemistry and biochemistry in the UCLA College and a senior author of the study. “At each step, we zoom in closer and see more and more details, and can now begin to deduce not just what the enzyme looks like, but also how it functions. Knowing that may lead to the development of new drugs that target specific parts of the enzyme.”In addition to reporting the highest level of detail ever seen of the structure of telomerase’s catalytic core, shown in the animation below, the researchers report for the first time they have captured telomerase in the process of making DNA.”For the first time, we have a framework, or blueprint, of telomerase,” said Lukas Susac, a UCLA postdoctoral scholar in Feigon’s laboratory and a co-lead author. “We know people have telomerase mutations and get sick, but we have had no understanding of how this came to be, beyond knowing their telomerase doesn’t work. Now we can say the problem is with a specific site within telomerase and perhaps see why the enzyme sometimes does not work properly. To treat an illness, first we have to locate where the problem occurs, and now this is possible. Of course, there are still steps to go.”Telomerase’s main job is to maintain the DNA in telomeres, the structures at the ends of human chromosomes. When telomerase is not active, each time the cells divide, the telomeres get shorter. When that happens, the telomeres eventually become so short that the cells stop dividing or die.Cells with abnormally active telomerase can continually rebuild their protective chromosomal caps and won’t die, said Feigon, who also is a member of UCLA’s Molecular Biology Institute and an associate member of the UCLA-Department of Energy Institute of Genomics and Proteomics. Over time, this is harmful because DNA errors accumulate and damage cells. Telomerase is especially active in cancer cells, which enables cancer to grow and spread.Feigon’s research team conducted the study using single-celled microorganisms called “Tetrahymena thermophila,” which are commonly found in freshwater ponds. Telomerase’s components are relatively well-known in Tetrahymena, and it is the organism in which telomerase and telomeres were first discovered. The central catalytic core of telomerase is similar in all organisms, including humans.Telomerase contains a specialized “reverse transcriptase,” or class of proteins, that has four major regions and several sub-regions. In this research, the scientists have revealed a large, previously unstudied sub-region called “TRAP” in the enzyme’s reverse transcriptase. Instead of copying from DNA to RNA — typically DNA makes RNA, which makes proteins — reverse transcriptases use RNA to make DNA; one that’s especially well-known is the HIV reverse transcriptase, the target of many drugs.Related StoriesLiving with advanced breast cancerEmbrace your natural skin tone to prevent skin cancer, say expertsNew protein target for deadly ovarian cancerWhile other reverse transcriptases can copy any arbitrary RNA sequence and make DNA out of it, telomerase’s reverse transcriptase copies only a specific six-nucleotide RNA and does so many times to make a long chain of DNA. (Nucleotides are the building blocks of DNA and RNA.) TRAP plays a crucial role in adding on small pieces of DNA to the ends of chromosomes to keep them from shortening every time cells divide.The researchers report for the first time the structure, shape and significance of TRAP, and the region with which it interacts.”A joy of science is the moment when you are the first person in the world to see something important,” said Feigon, a member of the National Academy of Sciences. “I remember looking at this structure when we got it and thinking we had solved a significant piece of the puzzle and were the only people who had seen this. It’s very exciting.”Feigon’s research team is learning how the regions interact and communicate with one another. In a 2015 study in the journal Science, Feigon and colleagues reported the location of a major region called “TEN.” Now the researchers report the structures of TEN and TRAP, and how they interact with each other and with the telomerase RNA. Many mutations that scientists attributed to the TEN region in fact disrupt TEN’s interaction with TRAP, the researchers report in Cell.This is the first time researchers have seen telomerase in the process of making DNA. The researchers captured telomerase immediately after it added a nucleotide to a growing DNA chain in the catalytic core. (The catalytic core consists of telomerase’s reverse transcriptase and an RNA.)What are the implications of the research for fighting cancers? Cancer cells keep reproducing, and for this to occur, telomerase must be highly active — which it is not in healthy cells. To reduce this, it would be useful to know how to target the enzyme’s activity. This new research brings this goal closer to reality by providing clues about what parts to target.”We have very deep insights into how telomerase works and how the components work together,” Susac said. “Each of these interactions could be a point to target, and possibly disrupt or enhance the function of telomerase. Precision will be very important; simply hitting telomerase with a hammer won’t work. Telomerase is a very central and unique enzyme in many organisms. Now we have locations to aim for.”The scientists used a technique called “cryo-electron microscopy” that enables them to see the enzyme in extraordinary detail, and used computational modeling to interpret their data. The research team has expertise in several fields, including biochemistry, molecular biology, computational biology and biophysics. Source:http://newsroom.ucla.edu/releases/scientists-see-inner-workings-of-enzyme-telomerase-which-plays-key-roles-in-aging-cancerlast_img read more

Breakthrough research gives insights on why glioblastomas regrow even after surgery

first_imgAug 2 2018A new study by KAIST researchers identified where the mutation causing glioblastoma starts. According to the study, neural stem cells away from the tumor mass are the cells of origin that contain mutation drivers for glioblastoma, one of the most aggressive brain tumor. This breakthrough research, reported in Nature on August 1, gives insights for understanding why glioblastomas almost always grow back, even after surgery, and suggests novel ways to treat glioblastoma, which was previously thought to be incurable.Like most cancers, glioblastoma is treated with surgery to remove as much of the tumor as possible, then radiation and chemotherapy. However, it almost always returns in less than a year and its median survival time is only 15 months. Precision therapeutic approaches targeting tumors themselves didn’t lead to any breakthroughs.Related StoriesResearchers measure EEG-based brain responses for non-speech and speech sounds in childrenWearing a hearing aid may mitigate dementia riskStudy provides new insight into longitudinal decline in brain network integrity associated with agingProfessor Jeong Ho Lee’s team at the Graduate School of Medical Science and Engineeringdescribed direct genetic evidence through the deep sequencing of all triple-matched samples: normal SVZ tissue away from the tumor mass, tumor tissue, and normal cortical tissue. The research team studied 28 patients with glioblastomas and other types of brain tumors who underwent supra-total resection or other surgical resections of tumors, providing access to normal subventricular zone (SVZ) tissue (where neural stem cells are located) away from the tumor mass. The researchers used various deep and single cell sequencing technologies to conduct comparative DNA analysis on the samples from the patient’s SVZ tissue and tumors.They reported that normal SVZ tissue away from the tumor in 56.3% of patients with glioblastoma already contained low-level glioblastoma driver mutations that were observed at high levels in their matching tumors. Furthermore, the research team generated a genome edited mouse carrying glioblastoma mutations in the SVZ and showed that neural stem cells with mutations migrate from the SVZ lead to the development of glioblastomas in distant brain regions. (See the image below)Professor Lee conducted this study in collaboration with Professor Seok-Gu Kang of the Brain Tumor Center at Severance Hospital of Yonsei University. He said, “It’s easier to understand when we compare it to fireworks. Every flare flying around sky can be likened to cancer cells even though the fireworks are triggered on the ground. We found the trigger.” The identification of this mutation pathway of glioblastomas will lead to a new paradigm for therapeutic strategies. He added, “Now, we can focus on interrupting the recurrence and evolution of glioblastomas.”Professor Lee has investigated mutations arising in the brain for a decade. He is developing innovative diagnostics and therapeutics for untreatable brain disorders including intractable epilepsy and glioblastoma at a tech-startup, SoVarGen. “All technologies we used during the research were transferred to the company. This research gave us very good momentum to reach the next phase of our startup,” he remarked. Source:http://www.kaist.ac.kr/_prog/_board/?mode=V&no=83742&code=ed_news&site_dvs_cd=en&menu_dvs_cd=060101&list_typ=B&skey=&sval=&smonth=&site_dvs=&GotoPage=last_img read more

Antiinflammatory use during surgery may lead to improved outcomes for cancer patients

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Sep 4 2018The world’s first clinical trial (SURGUVANT) evaluating anti-inflammatory use at the time of surgery in colon cancer patients to improve their cancer outcome has been published in scientific journal, BMC Cancer.The research successfully tested an anti-inflammatory agent with anti-cancer properties known as ‘Taurolidine’ in the SURGUVANT trial which was funded by a grant from Geistlich Pharma AG, Wolhusen, Switzerland. The research was undertaken by researchers at RCSI in Dublin in collaboration with the Cork University Hospital group, University College Cork, Mercy University Hospital and the Bon Secours Hospital, Cork led by Professor Paul Redmond, RCSI Council member and Chair of Surgery at Cork University Hospital and Mr Peter O’Leary, CUH Department of Surgery.Related StoriesLiving with advanced breast cancerBacteria in the birth canal linked to lower risk of ovarian cancerStudy: Nearly a quarter of low-risk thyroid cancer patients receive more treatment than necessaryThe Surguvant trial examined a link between surgical inflammation and the recurrence of cancer. The trial randomized patients undergoing surgery for colon cancer to either a placebo or 2% Taurolidine solution. The trial reported that important components of the inflammatory response to surgery that have been shown to propagate tumor cell growth, can be attenuated successfully without compromising patient safety.”We are delighted that this important clinical trial could be performed in Ireland. The Surguvant trial is the first of its kind to be performed worldwide showing that it is safe to use Taurolidine in this critical period of time for cancer patients where they are exposed to an inflammatory response necessary for wound healing but which can be potentially detrimental to their cancer outcome,” said Professor Redmond. “Now that we have proven the safety of this treatment strategy, it remains to be demonstrated if targeting the inflammatory response to surgery will lead to improved outcomes for cancer patients. We hope to do this in much larger future trials.” Source:http://www.rcsi.ie/index.jsp?p=100&n=110&a=11602last_img read more

Sugar pills may help treat certain chronic pain patients

first_img Prescribing non-active drugs rather than active drugs. “It’s much better to give someone a non-active drug rather than an active drug and get the same result,” Apkarian said. “Most pharmacological treatments have long-term adverse effects or addictive properties. Placebo becomes as good an option for treatment as any drug we have on the market.” Eliminating the placebo effect from drug trials. “Drug trials would need to recruit fewer people, and identifying the physiological effects would be much easier,” Apkarian said. “You’ve taken away a big component of noise in the study.” Reduced health care costs. A sugar pill prescription for chronic pain patients would result in vast cost savings for patients and the health care system, Apkarian said. Reviewed by Kate Anderton, B.Sc. (Editor)Sep 12 2018Someday doctors may prescribe sugar pills for certain chronic pain patients based on their brain anatomy and psychology. And the pills will reduce their pain as effectively as any powerful drug on the market, according to new research.Northwestern Medicine scientists have shown they can reliably predict which chronic pain patients will respond to a sugar placebo pill based on the patients’ brain anatomy and psychological characteristics.”Their brain is already tuned to respond,” said senior study author A. Vania Apkarian, professor of physiology at Northwestern University Feinberg School of Medicine. “They have the appropriate psychology and biology that puts them in a cognitive state that as soon as you say, ‘this may make your pain better,’ their pain gets better.”There’s no need to fool the patient, Apkarian said.”You can tell them, ‘I’m giving you a drug that has no physiological effect but your brain will respond to it,'” he said. “You don’t need to hide it. There is a biology behind the placebo response.”Related StoriesEngineered stem cells offer new treatment for metastatic bone cancerMarijuana isn’t a great choice for glaucoma treatment, says expertOpioid overdose deaths on the decline says CDC but the real picture may still be grimThe study was published Sept. 12 in Nature Communications.The findings have three potential benefits: How the study workedAbout 60 chronic back pain patients were randomized into two arms of the study. In one arm, subjects didn’t know if they got the drug or the placebo. Researchers didn’t study the people who got the real drug. The other study arm included people who came to the clinic but didn’t get a placebo or drug. They were the control group.The individuals whose pain decreased as a result of the sugar pill had a similar brain anatomy and psychological traits. The right side of their emotional brain was larger than the left, and they had a larger cortical sensory area than people who were not responsive to the placebo. The chronic pain placebo responders also were emotionally self-aware, sensitive to painful situations and mindful of their environment.”Clinicians who are treating chronic pain patients should seriously consider that some will get as good a response to a sugar pill as any other drug,” Apkarian said. “They should use it and see the outcome. This opens up a whole new field.”Source: https://www.northwestern.edu/last_img read more

Vaccine opponents attack US science panel

first_img Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe John Bazemore/AP Photo ACIP members, mostly physicians, review reams of data, then develop and vote on recommendations for vaccines ranging from niche to universal. At last week’s meeting, for instance, they considered tweaks to the schedule for vaccinating travelers to Asia and the western Pacific against Japanese encephalitis. They were also briefed on new studies as they consider whether to recommend that U.S. adults aged 27 through 45 consider getting vaccinated against the cancer-causing human papillomavirus. The 75-minute public comment period came at the end of the technical presentations.“This is kind of ground zero where these decisions are being made,” says Lynette Barron, a radio talk show host from Pell City, Alabama, who says her 3- and 5-year-old daughters were harmed by vaccines. Barron has attended ACIP meetings since early 2017; back then, “I was here by myself,” she says. But last year, she launched the Facebook page “Inundate the CDC ACIP Meetings.” Some 20 vaccination opponents showed up at ACIP’s June 2018 meeting. The October 2018 meeting drew perhaps 50, she says. That event grew so tense that in January, CDC issued new rules of conduct, warning members of the public to expect metal detectors at the doors and putting them on notice that the chair would eject them for disruptive behavior. K. J. Moore, a traveling nurse, told a Centers for Disease Control and Prevention vaccine panel last week that she is upset by mandates that health care workers receive the flu vaccine. Last week, police guarded the doors as a crowd filled 165 public seats in CDC’s auditorium; at least 80 attendees were vaccine opponents. They came from as far away as Iowa, Massachusetts, and California, Barron says. For the first time, committee members were roped off from the public—a setup that mirrors the vaccination controversy in the country at large, says Bernice Hausman, a cultural theorist at Pennsylvania State University’s College of Medicine in Hershey. “On one side is evidence-based, dispassionate discourse; on the other, citizens making emotional appeals, using alternative evidence, or telling personal stories. … The two don’t seem to meet,” says Hausman, whose book, Anti/Vax: Reframing the Vaccination Controversy, will be published in April.Forty-five people had asked to offer public comment; only a score, drawn by lottery, could be accommodated. All but two of the speakers attacked vaccinations and the committee. “I can’t explain why suddenly things shifted after so many years with relatively modest public comments,” says ACIP member Kelly Moore, who until recently directed the Tennessee Immunization Program and is an assistant clinical professor of health policy at the Vanderbilt University School of Medicine in Nashville. “But it’s our duty to listen … and to make sure that we are aware of what public sentiment is.”One reason vaccination opponents have begun to turn out at ACIP may be that they are disappointed in President Donald Trump, says Paul Offit, who directs the Vaccine Education Center at the Children’s Hospital of Philadelphia in Pennsylvania. A “vaccine safety and scientific integrity” commission that Trump promised to set up soon after he was elected never materialized, for example. Offit suggests vaccine opponents felt “they had their man in the White House—that things were gonna happen for them. And they didn’t.”Despite the emotion and determination of vaccine resisters, U.S. vaccination rates among young children remain robust. A 2017 CDC analysis found more than 90% of toddlers had received most recommended vaccines, and only 1.3% of children born in 2015 had received none of the 14 recommended early-childhood vaccinations—a quadrupling from the 0.3% figure in 2001, but still a tiny fraction. (The refusal rate is higher in some geographical pockets, several of which are now battling measles outbreaks.)The increasingly vituperative public attacks can be tough on ACIP scientists, however. “How does it feel knowing that your vote killed my son?” one woman asked the panel in October 2018. But Romero doubts the protests will make it tougher to recruit experts to serve on the committee. “It would take a lot to make us not come,” he says, calling the position “the pinnacle of public health impact. … Most of us consider this an extremely high honor to be here.”*Correction, 12 March, 12:55 p.m.: This story has been updated to reflect Kelly Moore’s current affiliation. Vaccine opponents attack U.S. science panel ATLANTA—The U.S. antivaccine movement has found a new front for its attacks on scientists and their work: gatherings of the Advisory Committee on Immunization Practices (ACIP), which recommends which vaccines Americans should receive. Since last summer, increasing numbers of vaccine opponents have come to ACIP meetings, held three times a year here at the campus of the Centers for Disease Control and Prevention (CDC), to vent their anger at the 15 buttoned-down experts on the panel during the public comments section—and to lambaste vaccination in general.“I do not consent to handing over my God-given children to the government of the United States of America,” Sandy Spaetti, who had traveled from Rockport, Indiana, said at ACIP’s meeting on 27 February, to raucous applause from dozens of other activists. “How is a vaccine that caused my son’s intestines to fold in on itself and almost die safe and effective?” asked Nicole Mason, a photographer from Jacksonville, Florida, who said she lost faith in all vaccines when her 4-month-old son developed intussusception, an intestinal obstruction, after receiving the rotavirus vaccine last summer. (The blockage occurs in an estimated one to five of every 100,000 infants vaccinated; it can also be caused by rotavirus infection itself.)“This may be the new normal. We don’t know. But it certainly is a lot more than we have seen in the past,” says ACIP’s new chair, José Romero, a pediatric infectious disease specialist at the University of Arkansas for Medical Sciences and Arkansas Children’s Hospital in Little Rock who has served on the panel for 4 years. Melinda Wharton, director of immunization services at the Centers for Disease Control and Prevention, listens to public comment during an Advisory Committee on Immunization Practices meeting last week. John Bazemore/AP Photo Sign up for our daily newsletter Get more great content like this delivered right to you! Country By Meredith WadmanMar. 4, 2019 , 1:10 PM Email Click to view the privacy policy. Required fields are indicated by an asterisk (*)last_img read more

NASA Got Sick of The Conspiracy Thing so Released Over 10000 Photos

first_imgIt was during the presidency of Dwight D. Eisenhower that the United States’ space program was launched. The program was given the codename “Apollo” and was put under the control of the National Aeronautics and Space Administration (NASA). It was only after Eisenhower had been succeeded by John F. Kennedy that the American public really learned the significance and purpose of this program: to put a man on the Moon.Surface of the moon. Photo by Project Apollo Archive CC BY 2.0At the time, the United States and the Soviet Union were embroiled in the infamous “space race”, with both nations eager to outdo the other and pursue new lengths of human exploration, beyond the very atmosphere of our own home planet.The Apollo program subsequently launched no less than 12 missions between 1969 and 1972, with half of them making it all the way to the Moon.Neil Armstrong photographs the Moon. Photo by Project Apollo Archive CC BY 2.0The first of the launches, Apollo 1, didn’t actually launch at all. It suffered a malfunction and wasn’t able to leave the Earth’s surface. Apollos 7 through 10, the next four launches, were orbiting missions to test various components and take photographs of the lunar surface elements.But it was Apollo 11 that would really go down in history. This mission — manned by Neil Armstrong, Michael Collins and Buzz Aldrin — not only made it to the Moon, but actually made a successful landing and allowed both Armstrong and Aldrin to step out onto it’s surface.American flag on the Moon. Photo by Project Apollo Archive CC BY 2.0The pair spent a couple of hours on their moonwalk, taking photos, recording their experiences, collecting rock samples, and planting the American flag, thereby putting a definitive end to the space race and sealing the United States’ status as the victor.Astronauts driving on the Moon. Photo by Project Apollo Archive CC BY 2.0Crew member, Michael Collins is often overlooked due to the fact that he stayed behind on the Command module, but he was integral to the mission’s success.Earth from the Moon. Photo by Project Apollo Archive CC BY 2.0As previously stated, several other missions made it to the Moon, but none could really generate the same excitement as Apollo 11. That incredible video of Neil Armstrong taking his first steps on the surface of the Moon has been seen and shared by millions, with many photos also being taken and released to the public in the wake of the mission.First human footprint on the Moon. Photo by Project Apollo Archive CC BY 2.0First Moon Landing. Photo by Project Apollo Archive CC BY 2.0In spite of all that evidence, however, as well as the proof from other successful space missions, there are many people who argue to this day that the whole thing was fake. In fact, the moon landings are one of the most popular subjects of debate for conspiracy theorists all over the world, with people suggesting various alternate explanations for the footage and photos.Some have argued that the whole thing was a hoax, drawn up by the American government to try and outdo Russia and earn popularity points with the public. Some have found alleged errors or inconsistencies in the footage to support their claims, with others suggesting that the whole thing was shot on a Hollywood film set, funded by Walt Disney and directed by Stanley Kubrick.Neil Armstrong put his left foot on the rocky Moon. Photo by Project Apollo Archive CC BY 2.0These conspiracy theories started many years ago and are still a hot topic in the modern era, especially with the recent emergence of the Flat Earth Movement and growing support for the idea that NASA has been lying to the public for decades. For a long time, NASA simply ignored the conspiracy theorists, but in 2016, the organization decided to make a big statement.The first photograph was taken by Neil Armstrong on the surface of the Moon, 1969. Photo by Project Apollo Archive CC BY 2.0NASA released over 10,000 photos of the first moon landing, uploading almost every single image ever taken on the Apollo missions on their public Flickr account for all to see and analyze.Read another story from us: Apollo 11 Tapes Made Public – NASA Releases 19,000 Hours of Historic AudioIn doing so, NASA effectively shut down a lot of the conspiracy theorists’ ideas; faking one film or a couple of photos might seem plausible enough, but faking thousands of shots from different angles, times, dates, and more would be a truly impossible undertaking.last_img read more

Stolen items recovered

first_img       As a result of last month’s theft ring bust by the Navajo County Sheriff’s Office, there has been a large quantity of property recovered from thefts that occurred in the area of Snowflake andSubscribe or log in to read the rest of this content. Bottom Ad April 2, 2019 Stolen items recoveredlast_img